Move the negative in front of the fraction.
Apply the product rule to .
Apply the product rule to .
Apply the product rule to .
Raise to the power of .
Multiply the exponents in .
Apply the power rule and multiply exponents, .
Multiply by .
Raise to the power of .
Multiply the exponents in .
Apply the power rule and multiply exponents, .
Multiply by .
Simplify ((w^4)/(-2u^3))^5